Detalhe da pesquisa
1.
Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice.
Drug Metab Dispos
; 52(2): 80-85, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38071551
2.
High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry.
Xenobiotica
; 54(2): 45-56, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38265764
3.
Prevalence and associated factors of locomotive syndrome in young Japanese adults: a cross-sectional study.
BMC Musculoskelet Disord
; 25(1): 366, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38730399
4.
Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes.
Drug Metab Dispos
; 51(2): 174-182, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36379710
5.
Theoretical Mechanistic Investigation of the Dynamic Kinetic Resolution of N-Protected Amino Acid Esters using Phase-Transfer Catalysts.
J Org Chem
; 88(12): 7748-7754, 2023 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36740818
6.
Suppressive effects of linzagolix, a novel non-peptide antagonist of gonadotropin-releasing hormone receptors, in experimental endometriosis model rats.
Clin Exp Pharmacol Physiol
; 50(7): 610-617, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37186405
7.
Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models.
Clin Exp Pharmacol Physiol
; 50(11): 914-923, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37622483
8.
Controlling the reactivity of La@C82 by reduction: reaction of the La@C82 anion with alkyl halide with high regioselectivity.
Beilstein J Org Chem
; 19: 1858-1866, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116242
9.
Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation.
Pharmacogenet Genomics
; 32(8): 288-292, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35997049
10.
Sleep duration and severe periodontitis in middle-aged Japanese workers.
J Clin Periodontol
; 49(1): 59-66, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34605052
11.
Pharmacological characterization of linzagolix, a novel, orally active, non-peptide antagonist of gonadotropin-releasing hormone receptors.
Clin Exp Pharmacol Physiol
; 49(10): 1082-1093, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35690889
12.
Non-clinical studies indicating lack of interactions between iron/calcium ions and linzagolix, an orally available GnRH antagonist.
Xenobiotica
; 52(5): 488-497, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35913106
13.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718425
14.
Nuclear receptor phosphorylation in xenobiotic signal transduction.
J Biol Chem
; 295(45): 15210-15225, 2020 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32788213
15.
Interruption of regular dental visits during the COVID-19 pandemic due to concerns regarding dental visits was associated with periodontitis in Japanese office workers.
J Periodontal Res
; 56(6): 1091-1098, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34432307
16.
In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice.
Xenobiotica
; 51(7): 764-770, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34013847
17.
A deep transfer learning approach for the detection and diagnosis of maxillary sinusitis on panoramic radiographs.
Odontology
; 109(4): 941-948, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34023953
18.
Changes in the screening efficacy of lower calf circumference, SARC-F score, and SARC-CalF score following update from AWGS 2014 to 2019 sarcopenia diagnostic criteria in community-dwelling older adults.
J Phys Ther Sci
; 33(3): 241-245, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33814711
19.
Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome.
BMC Biotechnol
; 20(1): 44, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32819341
20.
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Mol Pharmacol
; 96(5): 600-608, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31455676